After I posted yesterday about the coronavirus memorial quilt, Cozygirl left a comment and asked: "Will you handstitch the piecing together or use a machine?"
Answer: machine all the way!
Several years ago I wrote a blog post about how I sew big postage stamp quilts together. I still use the same method, and indeed the same little ziplock bags with numbers on them. (On both sides, because you never know which side will be up at any given moment.)